Automation Specialist

[rtamir1@live.com]

RAMI TAMIR
343 N. Genesee • Los Angeles, CA. 90036 • (310) 806-3622
rtamir1@live.com
SUMMARY
Over 16 years experience in the pharmaceutical industry with expertise in high-throughput bioassay drug-discovery screening including HTS data-analysis and data-management. In addition, I have developed expertise with HTS automation-laboratory design and set-up through knowledge of and experience with multiple automation systems and supportive software solutions.

PROFESSIONAL EXPERIENCE

Celgene 2008-Present
Scientist, Biology Group
 Assess and implement laboratory automation technologies and supportive software
o HTS robotic systems with custom programming set-up and performance
o HTS analytical software set-up and performance
o QC Monitoring evaluation and review of system performance
 High throughput bioassay screens for selected targets
o Participate in technical discussions regarding bioassays and determine appropriate issue resolution
o Define and implement procedures and SOPs
o Ensure testing is completed by established deadlines
o Study Reports writing
 Training of less experienced peers with bioassays, automation use, programming, data analysis, and database applications
 Manage compound Sample Bank inventory and tracking
 Develop and support laboratory information management systems

Amgen 1994-2007
Associate Scientist, Neuroscience Group
 Transient receptor potential (TRP) ion channels
o In-vitro bioassays for TRP-V1 cation channel 1st Generation and 2nd Generation SAR
o Drug in-vitro QC for Phase 1 clinical trial
o Discovery bioassays to identify drug candidates for multiple TRP channels
o Set-up primary DRG neuronal cultures to confirm drug activity on endogenous targets
o Contributions to SAR meetings, patent submission, literature manuscripts, and scientific meetings
 Retinal Degeneration
o Retinal ganglion bioassays to identify neurotrophic factors
o Photoreceptor neuronal bioassays to identify neurotrophic factors
o Neurotrophin discovery screening by expression cloning
o Quantitative methods for retinal degeneration in-vivo models
o in-vitro drug discovery survival-assays of retinal degeneration models
 Parkinson’s
o Dopaminergic primary cultures to identify survival factors
o Novel GDNF isoforms activity profiling

AREAS OF EXPERTISE
High throughput screening bioassays
High throughput laboratory design, set-up and programming (Beckman/Tecan/Perkin Elmer)
Data analysis and management
Tissue culture and tissue dissection
Functional assays (aequorin, cytotox, apoptosis, proliferation, luciferase, MetaFluor imaging, FLIPR)
Histochemistry based assays (immunostaining, Elisa, TRF, Array printing, FACS)
Molecular biology methods (RNA purification, PCR, gel electrophoresis, transfections, Western blots)
PC/Mac proficiency (Word, Excel, PowerPoint, Prism, ActivityBase, CambridgeSoft)

EDUCATION
MS in Bioinformatics, estimated completion 2012
MBA, estimated completion 2012
University of Maryland, Adelphi, MD

BS, Microbiology, 1994
California Polytechnic State University, San Luis Obispo, CA
PUBLICATIONS