Automated High Throughput
Pharmacological System, HT-PS^® 100

Presented at the May 25^th, 1999 meeting of the San Diego LRIG

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Table of Contents

Topics to be Covered

HT-PS® 100 (US PN 5,804,436)

HT-PS® Fluidics Configurations

"On-rate" Experimental Set-up

"Off-rate" Experimental Set-up

HT-PS® Automation

HT-PS® 100: Hit Identification

HT-PS® 100: Potency Profiling

LIMS - Experiment Registration

LIMS - HT-PS File Submission

LIMS - HT-PS Data Processing

HT-PS® 100 (US PN 5,804,436)

HEK293-5HT2A Cells
Schild Analysis: "On-rate" vs. "Off-rate"

TE671 Cells, Schild Analysis (on-rate):
Atropine is a Competitive Antagonist of M3 Receptor

TE671 Cells, Schild Analysis (on-rate):
Arachidonic Acid as a Non-competitive Antagonist of M3 Receptor

TE671 Cells, Schild Analysis (on-rate):
Verapamil as Un-competitive Antagonist of M3 Receptor

Author: Ilya Okun, Ph.D. - Vice President of Cell Pharmacology

Email: ilya@axiombio.com

Home Page: http://www.axiombio.com/

Other information:
AXIOM Biotechnologies, Inc. 3550 General Atomics Court San Diego, CA 92121

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